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KMID : 1123920100240030446
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.446 ~ p.451
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Immunomodulatory Effects of Orally Administrated Capsicum Extract on Peyer’s Patches
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Park Min-Young
Kim Dong-Hee
Jin Mi-Rim
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Abstract
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We investigated whether oral administration with capsicum extract (Capsicum annuum var. cheongyang) would affect the immune system by examining the immune cells of Peyer’s patch (PP), a gut associated lymphoid tissue, ex vivo. The mice were orally administrated with capsicum extract (100 mg/kg/day), capsaicin (10 mg/Kg), and the vehicle for four consecutive days, and PPs were isolated from intestines 2 days later. When the PP cells were cultured in the presence of Concanavalin A for 72 hr, the levels of cytokines, including IL-2 and IFN-, were dramatically increased, while the levels of IL-4 remained unchanged compared with the control. Data from the FACS analysis of PP cells indicated that capsicum extract significantly increased the number of CD3+ and CD4+ T cells as well as CD 19+ B cells compared with the control but not CD11b+ cells. Furthermore, the percentages of IL-2+ /CD4+ cells and IFN-/CD4+ were greatly increased. These data suggested that oraladministration with capsicum extract might activate the CD4+ T cells leading to cytokine production as well as CD19+ B cells in Peyer’s patches. As such, capsicum extract might have potential as an immune modulating agent.
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KEYWORD
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capsicum extract, Peyer’s patch, cytokine, T cell, B cell
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